|
Appendicitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
With this study we investigated the contribution of IL-6 (-572G/C rs1800796) and IL-6R (1:G.154448302 T > C rs7529229) polymorphisms on pathogenesis, and severity of AA in pediatric patients with AA: These results will guide further genetic researches to be performed on the role of IL-6 and IL-6R in AA.
|
26714766 |
2015 |
|
Acute appendicitis NOS (disorder)
|
|
0.010 |
GeneticVariation
|
BEFREE |
With this study we investigated the contribution of IL-6 (-572G/C rs1800796) and IL-6R (1:G.154448302 T > C rs7529229) polymorphisms on pathogenesis, and severity of AA in pediatric patients with AA: These results will guide further genetic researches to be performed on the role of IL-6 and IL-6R in AA.
|
26714766 |
2015 |
|
Coronary Artery Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
We investigated the relationships between single nucleotide polymorphisms (SNPs) of the interleukin (IL)-6 gene 174 G>C (rs1800795), 572 G>C (rs1800796), and 597 G/A (rs1800797) and coronary artery disease (CAD) risk in a Chinese population.
|
25299085 |
2014 |
|
Sleep Apnea, Obstructive
|
|
0.020 |
GeneticVariation
|
BEFREE |
We found VWF rs1063856 (OR = 1.50, 95% CIs = 1.10-2.04; p = 0.010), IL-6 rs1800796 (OR = 1.32, 95% CIs = 1.11-1.56; p = 0.002), TNF rs1800629 (OR = 1.44, 95% CIs = 1.13-1.83; p = 0.003), and CRP rs2794521 (OR = 1.27, 95% CIs = 1.04-1.55; p = 0.021) were all significantly associated with increased susceptibility of OSA, while VWF rs1063856 (OR = 1.75, 95% CIs = 1.18-2.62; p = 0.006), IL-6 rs1800796 (OR = 1.39, 95% CIs = 1.10-1.76; p = 0.006) were associated with the severity of OSA.
|
31210414 |
2019 |
|
Coronary heart disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
We found that the C allele of rs1800796 within <i>IL-6</i> and T allele of rs2228570 within <i>VDR</i> gene, interaction between rs1800796 and smoking were all associated with increased CHD risk.
|
29108239 |
2017 |
|
Obesity
|
|
0.020 |
GeneticVariation
|
BEFREE |
We found that IL-1B rs1864169 and IL-6 rs1800796 polymorphisms may interact with diabetes, hypertension and obesity.
|
24782217 |
2014 |
|
Diabetes Mellitus
|
|
0.020 |
GeneticVariation
|
BEFREE |
We found that IL-1B rs1864169 and IL-6 rs1800796 polymorphisms may interact with diabetes, hypertension and obesity.
|
24782217 |
2014 |
|
Diabetes
|
|
0.020 |
GeneticVariation
|
BEFREE |
We found that IL-1B rs1864169 and IL-6 rs1800796 polymorphisms may interact with diabetes, hypertension and obesity.
|
24782217 |
2014 |
|
Metabolic Syndrome X
|
|
0.010 |
GeneticVariation
|
BEFREE |
We demonstrate an association between the rs1800796 genetic variant of the IL-6 gene with components of MetS including BMI, and HDL-cholesterol, but not the MetS itself.
|
30989422 |
2019 |
|
Cerebral Thrombosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
We conducted a case-control study to investigate the influence of IL6 -174G/C (rs1800795) and -572C/G (rs1800796) genetic variants on the development of cerebral thrombosis in a Chinese population.
|
26662441 |
2015 |
|
Thrombosis of cerebral veins
|
|
0.010 |
GeneticVariation
|
BEFREE |
We conducted a case-control study to investigate the influence of IL6 -174G/C (rs1800795) and -572C/G (rs1800796) genetic variants on the development of cerebral thrombosis in a Chinese population.
|
26662441 |
2015 |
|
Cerebral arterial thrombosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
We conducted a case-control study to investigate the influence of IL6 -174G/C (rs1800795) and -572C/G (rs1800796) genetic variants on the development of cerebral thrombosis in a Chinese population.
|
26662441 |
2015 |
|
Neoplasms
|
|
0.020 |
GeneticVariation
|
BEFREE |
We assessed how these tumor markers were associated with use of anti-inflammatory drugs, polymorphisms in the IL6 genes (rs1800795 and rs1800796) and dietary antioxidants.
|
19452524 |
2009 |
|
Osteoporosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
Using the meta-analysis approach, the present study is designed to provide a relatively comprehensive picture of the relationship between bone mineral density (BMD) or osteoporosis and polymorphisms in the promoter region of IL-6 (rs1800795 and rs1800796).
|
23760743 |
2014 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.040 |
GeneticVariation
|
BEFREE |
Two common polymorphisms in the promoter of the IL-6 encoding gene IL6, -174G>C (rs1800795) and -573G>C (rs1800796), have been investigated for association with type 2 diabetes in numerous studies but with results that have been largely equivocal.
|
17003362 |
2006 |
|
Tooth Loss
|
|
0.010 |
GeneticVariation
|
BEFREE |
To examine the association between an IL6 (Interleukin-6) polymorphism (C-634G or rs1800796) and tooth loss, and an interaction between the polymorphism and smoking habits for the loss.
|
26011111 |
2015 |
|
Head and Neck Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study observed a positive association between poor oral hygiene and HNC, which appeared to differ by alcohol or cigarette consumption and the genotypes of IL6 rs1800796.
|
23948049 |
2013 |
|
Malignant Head and Neck Neoplasm
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study observed a positive association between poor oral hygiene and HNC, which appeared to differ by alcohol or cigarette consumption and the genotypes of IL6 rs1800796.
|
23948049 |
2013 |
|
Endometriosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study investigated the possibility of K469E (rs5498) and G241R (rs1799969) polymorphisms, in ICAM-1 gene, and G634C (rs1800796), in IL-6 gene, being associated with the occurrence of endometriosis in a sample of Brazilian women.
|
27614631 |
2016 |
|
Celiac Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study aimed to investigate polymorphisms in the genes responsible for encoding cytokines interleukin-6 (IL-6) (-572G/C) (rs1800796) and IL-17 (-197A/G) (rs2275913) in patients with celiac disease (CD).
|
28928101 |
2017 |
|
Diabetic Nephropathy
|
|
0.020 |
GeneticVariation
|
BEFREE |
This meta-analysis indicated that IL-6 rs1800795, rs1800796 and rs1800797 played important roles in DN development while IL-6 rs2069837 and rs2069840 might not be related to DN.
|
31451183 |
2019 |
|
Respiratory Distress Syndrome, Adult
|
|
0.010 |
GeneticVariation
|
BEFREE |
The TNF-α rs1800629 locus A allele and the IL-6 rs1800796 locus G allele were found to be risk factors for ARDS (adjusted OR = 1.452, 95% CI: 1.211-1.689, P < .001 and adjusted OR = 1.205, 95% CI: 1.058-1.358, P = .005, respectively).
|
31261506 |
2019 |
|
Stomach Carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
The stratified analysis showed that rs1</span>800796</span> G allele carriers (GG/CG) were associated with an increased risk of gastri</span>c cancer in the following subgroups: age >64 years old (OR<sub>adjusted</sub> = 1.67, 95% CI = 1.17-2.39), female (OR<sub>adjusted</sub> = 1.82, 95% CI = 1.09-3.05), positive for <i>H. pylori</i> infection (OR<sub>adjusted</sub> = 1.54, 95% CI = 1.07-2.22), non-cardiac gastric cancer (OR<sub>adjusted</sub> = 1.53, 95% CI = 1.15-2.04), stage T3-T4 tumor (OR<sub>adjusted</sub> = 1.41, 95% CI = 1.06-1.88), and gastric cancer with median to high differentiation (OR<sub>adjusted</sub> = 1.45, 95% CI = 1.08-1.96).
|
31312381 |
2019 |
|
Malignant neoplasm of stomach
|
|
0.040 |
GeneticVariation
|
BEFREE |
The stratified analysis showed that rs1</span>800796</span> G allele carriers (GG/CG) were associated with an increased risk of gastri</span>c cancer in the following subgroups: age >64 years old (OR<sub>adjusted</sub> = 1.67, 95% CI = 1.17-2.39), female (OR<sub>adjusted</sub> = 1.82, 95% CI = 1.09-3.05), positive for <i>H. pylori</i> infection (OR<sub>adjusted</sub> = 1.54, 95% CI = 1.07-2.22), non-cardiac gastric cancer (OR<sub>adjusted</sub> = 1.53, 95% CI = 1.15-2.04), stage T3-T4 tumor (OR<sub>adjusted</sub> = 1.41, 95% CI = 1.06-1.88), and gastric cancer with median to high differentiation (OR<sub>adjusted</sub> = 1.45, 95% CI = 1.08-1.96).
|
31312381 |
2019 |
|
IGA Glomerulonephritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The rs16944 in <i>IL-1B</i> and rs1800796 in <i>IL-6</i> were associated with 1.23-fold (95% CI, 1.02-1.48, P = 0.031) and 1.33-fold (95% CI, 1.11-1.66, P = 0.003) increases in the risk of developing IgAN, respectively.
|
29069743 |
2017 |